EGFR敏感突变阳性患者，接受靶向药还是免疫治疗？

目前的临床研究显示，免疫治疗对EGFR突变NSCLC人群的疗效差强人意，这与基础的细胞学研究有所不同，也说明了机体的复杂性。
EGFR突变造成免疫治疗疗效不佳的原因与EGFR突变造成免疫逃逸和耐药有关，具体机制可能是重塑肿瘤细胞周围的环境形成“冷肿瘤”、PD-L1低表达、淋巴细胞浸润减少、低TMB等共同造成。

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