JCOG9104研究纳入231例局限期SCLC,随机接受同步放化疗或序贯化放疗,化疗方案采用EP方案,结果显示,同步放化疗组患者的中位总生存时间(overall survival,OS)为27.2个月,5年生存率为23.7%,序贯化放疗组患者的中位OS为19.7个月,5年生存率为18.3%。
Takada M,Fukuoka M,Kawahara M,et al. Phase Ⅲ study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer:results of the Japan Clinical Oncology Group Study 9104[J]. J Clin Oncol, 2002, 20(14) :3054-3060. DOI:10.1200/ JCO.2002.12.071.
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