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作者：SCI天天读
SCI
3 April 2024
Lung-function trajectories: relevance and implementation in clinical practice
（IF: Lancet, 168.9）
Melén E, Faner R, Allinson JP, Bui D, Bush A, Custovic A, Garcia-Aymerich J, Guerra S, Breyer-Kohansal R, Hallberg J, Lahousse L, Martinez FD, Merid SK, Powell P, Pinnock H, Stanojevic S, Vanfleteren LEGW, Wang G, Dharmage SC, Wedzicha J, Agusti A; CADSET Investigators. Lung-function trajectories: relevance and implementation in clinical practice. Lancet. 2024 Mar 12:S0140-6736(24)00016-3.
Lung development starts in utero and continues during childhood through to adolescence, reaching its peak in early adulthood. This growth is followed by gradual decline due to physiological lung ageing. Lung-function development can be altered by several host and environmental factors during the life course. As a result, a range of lung-function trajectories exist in the population. Below average trajectories are associated with respiratory, cardiovascular, metabolic, and mental health comorbidities, as well as with premature death. This Review presents progressive research into lung-function trajectories and assists the implementation of this knowledge in clinical practice as an innovative approach to detect poor lung health early, monitor respiratory disease progression, and promote lung health. Specifically, we propose that, similar to paediatric height and weight charts used globally to monitor children’s growth, lung-function charts could be used for both children and adults to monitor lung health status across the life course. To achieve this proposal, we introduce our free online Lung Function Tracker tool. Finally, we discuss challenges and opportunities for effective implementation of the trajectory concept at population level and outline an agenda for crucial research needed to support such implementation.
肺的发育始于子宫，从儿童时期一直持续到青春期，在成年初期达到顶峰。这种增长随后由于生理性肺衰老而逐渐下降。在生命过程中，肺功能的发育可能受到多种宿主和环境因素的影响。因此，在人群中存在一系列肺功能轨迹。低于平均水平的轨迹与呼吸、心血管、代谢和心理健康合并症以及过早死亡有关。这篇综述介绍了对肺功能轨迹的渐进研究，并有助于将这一知识作为一种创新方法，在临床实践中应用，以早期检测肺部健康状况不佳，监测呼吸道疾病进展，促进肺部健康。具体来说，我们建议，与全球用来监测儿童生长的儿科身高和体重图表类似，肺功能图表可用于儿童和成人，以监测整个生命过程中的肺健康状况。为了实现这一建议，我们推出了免费的在线肺功能跟踪器工具。最后，我们讨论了在人群层面上有效实施轨迹概念的挑战和机遇，并概述了支持此类实施所需的关键研究议程。
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