作者：SCI天天读
SCI
13 December 2023
Cancer Evolution: A Multifaceted Affair
(Cancer Discovery, IF: 28.2)
Giovanni Ciriello, Luca Magnani, Sarah J. Aitken, Leila Akkari8, Sam Behjati, Douglas Hanahan, Dan A. Landau, Nuria Lopez-Bigas, Darío G. Lupiáñez, Jean-Christophe Marine, Ana Martin-Villalba, Gioacchino Natoli, Anna C. Obenauf, Elisa Oricchio, Paola Scaffidi, Andrea Sottoriva, Alexander Swarbrick, Giovanni Tonon, Sakari Vanharanta, and Johannes Zuber
CORRESPONDENCE TO: luca.magnani@icr.ac.uk
Abstract 摘要
Cancer cells adapt and survive through the acquisition and selection of molecular modifications. This process defines cancer evolution. Building on a theoretical framework based on heritable genetic changes has provided insights into the mechanisms supporting cancer evolution. However, cancer hallmarks also emerge via heritable nongenetic mechanisms, including epigenetic and chromatin topological changes, and interactions between tumor cells and the tumor microenvironment. Recent findings on tumor evolutionary mechanisms draw a multifaceted picture where heterogeneous forces interact and influence each other while shaping tumor progression. A comprehensive characterization of the cancer evolutionary toolkit is required to improve personalized medicine and biomarker discovery.
癌症细胞通过获得和选择分子修饰来适应和存活。这个过程定义为癌症的进化。建立在基于可遗传基因变化的理论框架，为支持癌症进化的机制提供了见解。然而，癌症特征也通过遗传的非遗传机制出现，包括表观遗传和染色质拓扑异构，以及肿瘤细胞与肿瘤微环境之间的相互作用。最近关于肿瘤进化机制的研究结果描绘了一幅多方面的画面，在塑造肿瘤进展的同时，异质机制相互作用并相互影响。对癌症进化工具包进行全面表征，以改进个性化医学和生物标志物的发现。
Significance 意义
Tumor evolution is fueled by multiple enabling mechanisms. Importantly, genetic instability, epigenetic reprogramming, and interactions with the tumor microenvironment are neither alternative nor independent evolutionary mechanisms. As demonstrated by findings highlighted in this perspective, experimental and theoretical approaches must account for multiple evolutionary mechanisms and their interactions to ultimately understand, predict, and steer tumor evolution.
肿瘤的进化是由多种赋能机制推动的。重要的是，遗传不稳定性、表观遗传重编码以及与肿瘤微环境的相互作用既不是替代性的，也不是独立的进化机制。正如这一观点中强调的发现所表明的那样，实验和理论方法必须考虑多种进化机制及其相互作用，才能最终理解、预测和指导肿瘤进化。
喜欢SCI天天读的理由
陪您一起学习SCI医学论文
每天5分钟，让自己的英语牛逼起来
特殊福利让您惊喜连连
复制链接或点击原文链接，即可下载SCI原文
W196N02
链接：https://pan.baidu.com/s/1v7vM5uReiKsIwTCaPMVQXA?pwd=gd0i
提取码：gd0i |
