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作者：SCI天天读
SCI
6 June 2023
Dissecting metastasis using preclinical models and methods
(Nat Rev Cancer, IF: 69.8)
Hebert Jess D,Neal Joel W,Winslow Monte M,Dissecting metastasis using preclinical models and methods.[J] .Nat Rev Cancer, 2023, 23: 391-407.
Metastasis has long been understood to lead to the overwhelming majority of cancer-related deaths. However, our understanding of the metastatic process, and thus our ability to prevent or eliminate metastases, remains frustratingly limited. This is largely due to the complexity of metastasis, which is a multistep process that likely differs across cancer types and is greatly influenced by many aspects of the in vivo microenvironment. In this Review, we discuss the key variables to consider when designing assays to study metastasis: which source of metastatic cancer cells to use and where to introduce them into mice to address different questions of metastasis biology. We also examine methodsthat are being used to interrogate specific steps of the metastatic cascade in mouse models, as well as emerging techniques that may shed new light on previously inscrutable aspects of metastasis. Finally, we explore approaches for developing and using anti-metastatic therapies, and how mouse models can be used to test them.
长期以来，转移一直被认为是导致绝大多数癌症相关死亡的原因。然而，我们对转移过程的理解以及预防或消除转移的能力，仍然令人沮丧、局限。这主要是由于转移的复杂性，这是一个多步骤的过程，可能因癌症类型而异，并且受到体内微环境许多方面的极大影响。在这篇综述中，我们讨论了在设计研究转移的实验时需要考虑的关键变量：使用转移癌细胞的来源以及在何处将它们引入小鼠以解决转移生物学的不同问题。我们还研究了用于探究小鼠模型中转移级联特定步骤的方法，以及可能揭示先前难以理解的转移方面的新技术。最后，我们探讨了开发和使用抗转移疗法的方法，以及如何使用小鼠模型来测试它们。
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原文地址：http://mp.weixin.qq.com/s?src=11×tamp=1686086184&ver=4575&signature=hUgkyiCaGttHyrzXTzT80ku9dE6GFepki3uSkUqWV0LY8xBm-*n4bJkxfKzif0PbPMk3utCeQxlbQp78V9nV1La6Wd7KRwXTU1rI79qoZYVCGcoSAIQTI6Irq8*dwS7Z&new=1 |
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