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作者：SCI天天读
SCI
25 February 2023
Mechanisms driving the immunoregulatory function of cancer cells
(Nat Rev Cancer;IF:69.8)
Correspondence to: k.d.visser@nki.nl，van Weverwijk A, de Visser KE. Mechanisms driving the immunoregulatory function of cancer cells. Nat Rev Cancer 2023
Tumours display an astonishing variation in the spatial distribution, composition and activation state of immune cells, which impacts their progression and response to immunotherapy. Shedding light on the mechanisms that govern the diversity and function of immune cells in the tumour microenvironment will pave the way for the development of more tailored immunomodulatory strategies for the benefit of patients with cancer. Cancer cells, by virtue of their paracrine and juxtacrine communication mechanisms, are key contributors to intertumour heterogeneity in immune contextures. In this Review, we discuss how cancer cell-intrinsic features, including genetic aberrations, signalling pathway deregulation and altered metabolism, play a key role in orchestrating the composition and functional state of the immune landscape, and influence the therapeutic benefit of immunomodulatory strategies. Moreover, we highlight how targeting cancer cell-intrinsic parameters or their downstream immunoregulatory pathways is a viable strategy to manipulate the tumour immune milieu in favour of antitumour immunity.
肿瘤在免疫细胞的空间分布、组成和激活状态方面显示出惊人的变化，这影响了肿瘤的进展和对免疫治疗的反应。阐明肿瘤微环境中控制免疫细胞多样性和功能的机制，将为开发更适合癌症患者的免疫调节策略铺平道路。癌细胞通过其旁分泌和近分泌的交流机制，是免疫环境中肿瘤异质性的关键因素。在这篇综述中，我们讨论了癌细胞的内在特征，包括遗传畸变、信号通路异常和代谢改变，如何在协调免疫环境的组成和功能状态中发挥关键作用，并影响免疫调节策略的治疗效果。此外，我们强调靶向癌细胞的固有特征或其下游免疫调节途径是一种可行的策略，以操纵肿瘤免疫环境，有利于抗肿瘤免疫
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链接：https://pan.baidu.com/s/1LfKEUJV8K8AIyTrRbxki1g
提取码：r1sp
原文地址：http://mp.weixin.qq.com/s?src=11×tamp=1677326730&ver=4372&signature=GXpWgBZPpYllVG2CSeEla163WPxlFh1mPHG0EHalhK*BpnCd9IiJPdghUjdioKnrYdS4IyJyJZ5nR3IHx5EmGntx2rIq4goVN4mhKUZgNUNBFVMDXiIiloRczR1PB0pn&new=1 |
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