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作者：SCI天天读
SCI
4 July 2023
mRNA-based cancer therapeutics
(IF: Nat Rev Cancer., 78.5)
Liu C, Shi Q, Huang X, Koo S, Kong N, Tao W. mRNA-based cancer therapeutics. Nat Rev Cancer. 2023 Jun 13. doi: 10.1038/s41568-023-00586-2. Epub ahead of print. PMID: 37311817.
Correspondence: kongna@zju.edu.cn; wtao@bwh.harvard.edu
Due to the fact that mRNA technology allows the production of diverse vaccines and treatments in a shorter time frame and with reduced expense compared to conventional approaches, there has been a surge in the use of mRNA-based therapeutics in recent years. With the aim of encoding tumour antigens for cancer vaccines, cytokines for immunotherapy, tumour suppressors to inhibit tumour development, chimeric antigen receptors for engineered T cell therapy or genome-editing proteins for gene therapy, many of these therapeutics have shown promising efficacy in preclinical studies, and some have even entered clinical trials. Given the evidence supporting the effectiveness and safety of clinically approved mRNA vaccines, coupled with growing interest in mRNA-based therapeutics, mRNA technology is poised to become one of the major pillars in cancer drug development. In this Review, we present in vitro transcribed mRNA-based therapeutics for cancer treatment, including the characteristics of the various types of synthetic mRNA, the packaging systems for efficient mRNA delivery, preclinical and clinical studies, current challenges and future prospects in the field. We anticipate the translation of promising mRNA-based treatments into clinical applications, to ultimately benefit patients.
与传统方法相比，mRNA技术可以在更短的时间内生产出多种不同疫苗和治疗方法，并且费用更低，因此近年来基于mRNA的疗法的使用激增。为了编码用于癌症疫苗的肿瘤抗原、用于免疫治疗的细胞因子、用于抑制肿瘤发展的肿瘤抑制剂、用于工程化T细胞治疗的嵌合抗原受体或用于基因治疗的基因组编辑蛋白，其中许多此类疗法在临床前研究中显示出有希望的疗效，有的甚至已进入临床试验。鉴于有证据支持临床批准的mRNA疫苗的有效性和安全性，再加上人们对基于mRNA的疗法的兴趣日益浓厚，mRNA技术有望成为癌症药物开发的主要支柱之一。在这篇综述中，我们介绍了用于癌症治疗的体外转录mRNA疗法，包括各种合成mRNA的特性、高效mRNA传递的包装系统、临床前和临床研究、该领域的当前挑战和未来前景。我们预计将有前景的基于mRNA的治疗方法转化为临床应用，最终可使患者受益。
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原文地址：http://mp.weixin.qq.com/s?src=11×tamp=1688593892&ver=4633&signature=oMtYyFPA7IXScpLJQgG*QwpVA4CTbLS01j7ZP-dCC-oVMycI-w6Dh5eCzFFnm*aDW7oO1U0whYvtKuycgUueiQq23a-8f2HHBEs-qF1W9EbBxAxN*ylLutfug5IIdftx&new=1 |
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