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[综合] 支气管肺 / 胸腺神经内分泌肿瘤的内科治疗方案

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阳光肺科 发表于 2023-6-15 07:25:46 | 显示全部楼层 |阅读模式

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长效奥曲肽
长效奥曲肽, 20~30mg,  肌内注射/深部肌肉注射, 第 1 天, 28 天 1 个周期

兰瑞肽
兰瑞肽, 120mg, 皮下注射, 第 1 天, 28 天 1 个周期

兰瑞肽
兰瑞肽, 40mg, 肌肉注射, 第 1 天, 每14 天 1 个周期

PRRT疗法(Peptide Receptor- Radionuclide Therapy肽受体-放射性核素治疗)
PRRT 200mCi(1mCi=3.7×107Bq) 静脉注射 第 1 天 每 8 周重复,共 4 次

索凡替尼
索凡替尼,300mg,口服,每天一次

舒尼替尼
舒尼替尼 37.5mg,口服,每天一次

依维莫司
依维莫司 10mg,口服,每日 1 次。
基于经验,CSCO 指南建议5mg,口服,每天1次为起始剂量

CAPTEM 方案
卡培他滨 750mg/m2  口服 第 1~14 天 每日 2 次
替莫唑胺 200mg/m2 口服 第 10~14 天 每日 1 次
每 4 周重复(注意两种药物的服药顺序)

EP 方案1
依托泊苷 100mg/m2 静脉输注 第 1~3 天
顺铂 75mg/m2  静脉输注 第 1 天
每 3 周重复,共 4~6 个周期

EP 方案2
依托泊苷 80mg/m2 静脉输注 第 1~3 天
顺铂 80mg/m2  静脉输注 第 1 天
每 3 周重复,共 4~6 个周期

EP 方案3
依托泊苷 100mg/m2 静脉输注 第 1~3 天
顺铂 25mg/m2  静脉输注 第 1~3 天
每 3 周重复,共 4~6 个周期

EC 方案
依托泊苷 100mg/m2 静脉输注 第 1~3 天
卡铂 AUC=5 静脉输注 第 1 天
每 3 周重复,共 4~6 个周期


依托泊苷单药
依托泊苷 50mg,口服,每天一次,第 1~10 天
每 3 周重复,治疗2~3周期复查

IP 方案1
伊立替康 60mg/m2 静脉输注 第 1、8、15天
顺铂 60mg/m2  静脉输注 第 1 天
每 4 周重复,共 4~6 个周期

IP 方案2
伊立替康 65mg/m2 静脉输注 第 1、8天
顺铂 30mg/m2  静脉输注 第 1 、8天
每 3 周重复,共 4~6 个周期

mFOLFOX6方案
奥沙利铂 85mg/m2 静脉输注2h 第 1 天
LV 400mg/m2,静脉输液2h,第1天
5-FU 400mg/m2,静脉推注,第1天;然后 1200mg/(m2·d)×2d,持续静脉输液(总量 2400mg/m2,输液46-48h)
每 2 周重复(请注意,这里没有写明周期数)

CAPOX方案
奥沙利铂 130mg/m2 静脉输注大于2h 第 1 天
卡培他滨 1000mg/m2,口服,每天2次,第1-14天
每 3 周重复(请注意,这里没有写明周期数)


更新:20240831

参考指南:
  • 中国临床肿瘤学会指南工作委员会.中国临床肿瘤学会 (CSCO) 小细胞肺癌诊疗指南2024.人民卫生出版社.北京 2024
  • 中国临床肿瘤学会指南工作委员会.中国临床肿瘤学会 (CSCO) 神经内分泌肿瘤诊疗指南2022.人民卫生出版社.北京 2022

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