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作者：CardiothoracicSurgery
*仅供医学专业人士参考
周围型磨玻璃为主型肺癌亚肺叶切除术后患者的长期预后:JCOG0804/WJOG4507L的最终报告
AATS 2023
原文标题
Long-term Outcome of Patients with Peripheral Ground Glass Opacity Dominant Lung Cancer After Sublobar Resections: Final Report of JCOG0804/WJOG4507L
作者及单位
David Jones , Invited Discussant , Memorial Sloan Kettering
Makoto Suzuki , Abstract Presenter , Kumamoto University
简介
在JCOG0201中，我们报道了低侵袭性病理类型的定义，并阐明了实变肿瘤之比（CTR）≤0.25、大小≤2 cm的肺癌(LC)可作为术前薄层CT诊断微侵袭性病理的较好的放射学指标。我们已经在前瞻性介入研究(JCOG0804/WJOG4507L)中报道了亚肺叶切除术的5年安全性和有效性。本最终分析的目的是阐明JCOG0804/WJOG4507L对具有此类放射学特征的周围型磨玻璃为主型(GGO)LC患者行亚肺叶切除术的10年预后情况。
方法
我们回顾性分析2007年1月至2022年8月因RHD行二尖瓣外科手术（MVR，MVr）368个病例，225例（61.14%）为MVr。53.03(13.4)、51.34(10.81)和 3.05、3.81 分别是 MVr、MVR 组的平均年龄和euroScore2中位数。同时也评估了围手术期数据和长期结果。
我们回顾性的分析了2009年5月至2011年4月从日本51家机构招募并随访至2021年5月6日333名患者(注册时中位年龄为62岁)。其中，314例患者接受了亚肺叶切除术(258例楔形切除术，56例肺段切除术)，11例患者中转肺叶切除术，8例患者不符合条件。作为一种介入性手术方法，可以进行楔形切除术，如果手术切缘不够，也可以进行肺段切除术。最终数据截止点的中位随访期为10.1年。
结果
314例行亚肺叶切除术患者的10年RFS和OS分别为98.6% (95% CI, 96.2 - 99.5%)和98.5% (95% CI, 96.1 - 99.4%)。切缘局部复发有1例。43例患者出现继发性肿瘤(13.7%:95% CI, 10.1 -18.0%)，其中19例为继发性肝癌(6.1%:95% CI, 3.7-9.3%)。
结论
JCOG0804/WJOG4507L的长期结果表明，对于周围型GGO为主型肺癌患者，亚肺叶切除术是一种可以完全治愈的手术方法。其他治疗方案的适应症将进一步研究。
作者简介
David Jones
Invited Discussant
Biography: David R. Jones, MD
Dr. Jones graduated Phi Beta Kappa from West Virginia University and received his medical degree from West Virginia University School of Medicine where he was AOA. He completed his Thoracic Surgery Residency at the University of North Carolina at Chapel Hill, NC. In 1999, Dr. Jones joined the faculty at the University of Virginia where he became Professor and Vice-Chairman of the Department. In 2013 Dr. Jones was recruited to Memorial Sloan Kettering Cancer Center as Chief of Thoracic Surgery.
Dr. Jones is Profes
sor & Chief of Thoracic Surgery and Executive Vice-chair of the Department of Surgery at MSKCC. He is also the Co-Director of the Fiona and Stanly Druckenmiller Center for Lung Cancer Research. He is the current Secretary of the AATS and Chair of the AATS-MSKCC Thoracic Surgery Oncology Group (TSOG) for clinical trials. Dr. Jones is Associate Editor for the Journal of Thoracic and Cardiovascular Surgery. He is recent past Chair of the NIH/NCI Tumor Progression and Metastasis (TPM) study section and currently serves on the NCI Board of Scientific Advisors. He serves on numerous national and international committees related to thoracic surgical research and clinical care.
Dr. Jones’s research focuses on mechanisms and drivers of metastases in lung cancer. His research has been funded by the NIH/NCI, Department of Defense, and the AACR. He has been the Principal Investigator or Co-PI on over 35 funded grants and currently holds 2 R01 awards from the NCI. He has published over 380 papers and has written over 35 book chapters. He was an early adopter of VATS anatomic resections and minimally-invasive esophagectomies and performs the majority of his operations using these minimally-invasive approaches.
Makoto Suzuki
Abstract Presenter
1989 Chiba University Hospital Pulmonary Surgery
1990 Department of Anesthesiology, Chiba University Hospital, Department of Intensive Care, Chiba Emergency Medical Center
1991 Odawara City Hospital Surgery
1993 Chiba University Hospital Pulmonary Surgery
1994 Department of Respiratory Medicine, Chiba Cancer Center
1995 Department of Pulmonary Surgery, Chiba University Hospital
1997 Department of Respiratory Medicine, Chiba Cancer Center
1998 Department of Thoracic Surgery, Omiya Red Cross Hospital
1999 Chiba University Hospital Pulmonary Surgery Assistant
2001 Postdoctoral fellow (University of Texas, USA)
2003 Chief Medical Officer, Department of Respiratory Medicine, Chiba Cancer Center
2005 Chiba University Hospital Respiratory Surgery Assistant
2008 Lecturer, Respiratory Surgery, Chiba University Hospital
2010 Professor, Department of Thoracic Surgery, Graduate School of Life Sciences, Kumamoto University
2021-Present Professor, Department of Respiratory Surgery and Breast Surgery, Graduate School of Life Sciences, Kumamoto University
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转自：心外时空
（翻译及审校：刘浩、吴思凯）
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