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[胸腺肿瘤] WHO胸腺肿瘤及纵隔肿瘤组织学分类(2021 第五版)

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一、上皮性肿瘤 Epithelial tumours
(一)胸腺瘤(thymomas)
8580/3 胸腺瘤, 非特指型 Thymoma, NOS
8581/3 胸腺瘤,A型  Thymoma,type A
8582/3 AB型胸腺瘤 thymoma,type AB
8583/3 B1型胸腺瘤 thymoma,type B1
8584/3 B2型胸腺瘤 thymoma,type B2  
8585/3 B3型胸腺瘤 thymoma,type B3
8580/1 微小结节性胸腺瘤伴淋巴样间质 micronodular thymoma with lymphoidstroma
8580/1 化生型胸腺瘤 metaplastic thymoma
9010/0 脂肪纤维腺瘤 lipofibroadenoma

(二)胸腺癌(包括胸腺神经内分泌上皮肿瘤)(thymic carcinoma)
  • 鳞状细胞癌(squamouscell carcinoma)
8070/3鳞状细胞癌,非特指 squamous cell carcinoma, NOS)
8123/3基底细胞样癌 basaloid carcinoma
8123/3淋巴上皮瘤样癌 lymphoepithelioma-like carcinoma
  • 腺癌(adenocarcinoma)
8140/3腺癌,非特指型  Adenocarcinoma, NOS
8260/3低级别乳头状腺癌(Low-grade papillary adenocarcinoma)
8200/3胸腺癌伴腺样囊腺癌样特征 (thymomawith adenoid cystic carcinoma-like features
8144/3 腺癌,肠型 Adenocarcinoma, enteric type
8560/3腺鳞癌 Adenosquamous carcinoma
  • NUT癌(NUTcarcinoma)
8023/3 NUT癌 (NUTcarcinoma)
  • 涎腺样癌 Salivary gland-like carcinomas
8430/3 黏液表皮样癌 Mucoepidermoid carcinoma
8310/3透明细胞癌 Clear cell carcinoma
8033/3肉瘤样癌 Sarcomatoid carcinoma
8980/3 癌肉瘤 Carcinosarcoma
  • 未分化癌 Undifferentiated carcinoma
8020/3癌,未分化,非特指 Carcinoma, undifferentiated, NOS
  • 胸腺癌 Thymiccarcinomas
8586/3胸腺癌,非特指 thymic carcinoma, NOS
  • 胸腺神经内分泌肿瘤 thymic neuroendocrine tumours
8240/3 类癌,非特指/神经内分泌瘤,非特指 Carcinoid tumor, NOS/neuroendocrinetumor, NOS
8240/3典型类癌/神经内分泌瘤,1级 Typical carcinoid/neuroendocrine tumor,grade 1
8249/3不典型类癌/神经内分泌瘤,2级 Typical carcinoid/neuroendocrine tumor,grade 1
  • 神经内分泌癌 Neuroendocrine carcinomas
8041/3小细胞癌 small cell carcinoma                                
8045/3混合性小细胞癌 combined small cell carcinoma
8013/3大细胞神经内分泌癌 large cellneuroendocrine  carcinoma

二、纵隔生殖细胞肿瘤 Germcell tumours of the mediastinum
9061/3 精原细胞瘤 seminoma
9070/3 胚胎性癌 embryonal carcinoma
9071/3 卵黄囊瘤 York sac tumour
9071/3 绒毛膜癌 choriocarcinoma
  • 畸胎瘤 teratoma
9080/0 成熟性畸胎瘤 teratoma,mature
9080/1 不成熟畸胎瘤 teratoma,immature
9085/3 混合性生殖细胞肿瘤 Mixed germ cell tumor
9084/3 畸胎瘤伴体细胞型恶性成分 Teratoma with somatic-typemalignancy
9086/3 生殖细胞肿瘤伴相关恶性血液肿瘤 germ cell tumour with associatedhaemotologic malignancy

三、胸腔间叶性肿瘤 Mesenchymal Tumors of the Thorax
  • 脂肪肿瘤Adipocytictumors
8850/0 脂肪瘤,非特指 Lipoma, NOS
8850/0 胸腺脂肪瘤 Thymolipoma
8850/3 脂肪肉瘤,非特指 Liposarcoma, NOS
8851/3 脂肪肉瘤,高分化 Liposarcoma, well differentiated
8852/3 黏液样脂肪肉瘤 Myxoid liposarcoma
8852/3 多形性脂肪肉瘤 pleomorphic liposarcoma
8858/3 去分化脂肪肉瘤  dedifferentiated liposarcoma
  • 纤维和纤维母细胞性肿瘤 Fibroblastic and myofibroblastic tumors
8858/3 韧带样型纤维瘤病 Desmoid-type fibromatosis
8815/1 孤立性纤维性肿瘤,非特指 solitary fibrous tumour,NOS
8817/0 钙化性纤维性肿瘤 Desmoid-type fibromatosis
8825/1 炎性肌纤维母细胞性肿瘤 Inflammatory myofibroblastic tumor
8825/1 粘液纤维肉瘤 Myxofibrosarcoma
  • 脉管肿瘤 vascularneoplasms
8825/1 血管瘤,非特指 Hemangioma, NOS
8825/1 海绵状血管瘤 cavernous hemangioma
8825/1 静脉血管瘤 Venous hemangioma
8825/1 肌内血管瘤 Intramuscular hemangioma
8825/1 动静脉血管瘤 Arteriovenous hemangioma
9170/0 淋巴管瘤,非特指 lyphangioma,NOS
9173/0 囊性淋巴管瘤 Cystic lymphangioma
9133/3 上皮样血管内皮细胞瘤 epithelioid hemangioendothelioma
9120/3 血管肉瘤 andiosarcoma
  • 骨骼肌肿瘤 Skeletal muscle tumors
8900/3 横纹肌肉瘤,非特指  Rhabdomyosarcoma, NOS
8910/3 胚胎型横纹肌肉瘤 Embryonal rhabdomyosarcoma
8912/3 梭形细胞横纹肌肉瘤 Spindle cell rhabdomyosarcoma
8912/3 腺泡状横纹肌肉瘤 Alveolar rhabdomyosarcoma
8901/3 多形性横纹肌肉瘤 Alveolar rhabdomyosarcoma
  • 外周神经鞘和神经肿瘤 Peripheral nerve sheath and neural tumors
8693/3 肾上腺外副神经节瘤 Extra-adrenal paraganglioma
9580/0 颗粒细胞瘤 Granular cell tumor
9580/3 颗粒细胞瘤,恶性 Granular cell tumor,malignant
9580/0 神经鞘瘤 Schwannoma
9540/3 恶性外周神经鞘瘤 Malignant peripheral nerve sheath tumor
9490/3 节细胞神经瘤 ganglioneuroma
9490/3 节细胞神经母细胞瘤 ganglioneuroblastoma
9500/3 神经母细胞瘤 neuroblastoma
  • 分化不明肿瘤 Tumorsof uncertain differentiation
9500/3 滑膜肉瘤,非特指 synovial sarcoma,NOS
9500/3 滑膜肉瘤,梭形细胞synovial sarcoma,spindlecell
9500/3 滑膜肉瘤,上皮样细胞synovial sarcoma,epithelioidcell
9043/3 滑膜肉瘤,双向型synovial sarcoma,biphasic
9043/3 尤文肉瘤 Ewing sarcoma
9367/3 CIC重排肉瘤 CIC-rearranged sarcomaI
9368/3 肉瘤伴BCOR基因改变Sarcomawith BCOR genetic alterations
9366/3 圆细胞肉瘤伴EWSR1-non-ETS融合 Round cell sarcoma with EWSR1-non-ETSfusions


以下淋巴造血肿瘤分类为2015 年第四版分类
纵隔淋巴瘤 lymphomaof the mediastinum 2015 年第四版)
原发性纵隔大B细胞淋巴瘤 Primarymediastinal large B-cell lymphoma
黏膜相关淋巴组织结外边缘区淋巴瘤 (MALT淋巴瘤) Extranodalmarginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
其它成熟B细胞淋巴瘤 otherature B-Cell lymphoma
T 淋巴母细胞白血病/淋巴瘤 T-ALL/LBLT lymphoblastic leukemia/lymphoma
间变大细胞淋巴瘤和其它少见成熟T和NK细胞淋巴瘤 Anaplasticlarge cell lymphoma and other rare mature T- and NK-Cell lymphomas
ALK阳性间变大细胞淋巴瘤 ALCL ,ALK-positive(ALK+)
ALK阴性间变大细胞淋巴瘤 ALCL ,ALK-negative(ALK-)
霍奇金淋巴瘤 Hodgkinlymphoma
B细胞淋巴瘤,不能分类,特征介于弥漫大B细胞淋巴瘤与经典型霍奇金淋巴瘤之间 B-cell lymphoma, unclassifiable, with features intermediatebetween diffuse large B-cell lymphoma and classical Hodgkin lymphoma

纵隔组织细胞及树状突细胞肿瘤 Histocytic and dendritic cell neoplasms of the mediastinum
朗格罕细胞病变 Langerhanscell lesions
朗格罕细胞组织细胞增多症 Langerhanscell histiocytosis(LCH)
朗格罕细胞肉瘤 Langerhanscell sarcoma(LCS)
组织细胞肉瘤 Histiocyticsarcoma
滤泡状树突细胞肉瘤 Folliculardendritic cell sarcoma(FDC)
指状突树突细胞肉瘤 Interdigitatingdendritic cell sarcoma(IDC)
纤维母细胞性网状细胞肿瘤 Fibroblasticreticular cell tumor
未确定的树状突细胞肿瘤 Indeterminatedendritic cell tumor

髓系肉瘤和髓外急性髓系白血病 Myeloid sarcoma and extramedullary acute myeloidleukemia

胸腺异位肿瘤 ectopic tumours of the thymoma
异位甲状腺肿瘤 ectopicthyroid tumours
异位甲状旁腺肿瘤 ectopicparathyroid tumours
其它见异位肿瘤 otherrare ectopic tumours



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