|
TemperingGreat Expectations With Realism 以现实主义调和远大期望 ctDNA(circulating tumour DNA) notcalculable [NC] notreached [NR] thesedrugs unleash antitumor immunity,resulting in tumor regression and improved survival. mayhave enhanced antitumor effectsowing to greater fitness of host immunity and reduced tumor clonalheterogeneity heprimary tumor may be leveraged as an antigensource for expansion and activation of tumor-specific T cells and systemic surveillanceof micrometastases aninflux of 大量涌入 TCR confersunique antigen specificity 赋予独特的抗原特异性 gaugeimmune-related responses Evidence for theproposed “immune-related pathologic response criteria” (irPRC) comes from aretrospective analysis of trial data from 20 patients with early-stage non–smallcell lung cancer (NSCLC) who received neoadjuvant nivolumab (Opdivo;Bristol-Myers Squibb) Toendorse any of these endpoints for neoadjuvant lung cancer supplanted chemotherapy 替代化疗 compatible with the 可共存 implicit evidence 隐含证据 insurveillance of MRD 在MRD的监测中 a hotly debated topic theoretical concern summarized the results of various studies narratively 叙事性的 sparing of critical organs byperforming less invasive surgery of smaller tumors confounding convert borderline unresectabletumors into resectable disease after tumor shrinkage a profound effect on 意义深远的 anecdotal reports significantadhesions and fibrosis 粘连和纤维化 elegantly demonstrated 优雅的展示 a moderate correlationbetween 适度相关 DFS is particularly useful insituations where extended survival makes measurement of OS impractical. 不切实际的 办不到的 discern differences insurvival 识别生存 差异 protracted follow up 拖延的 持久的 adopted 接受 领养 采用 methodological rigor 方法学严密性 imperative 势在必行的 The consensus of data 一致的数据显示 compensatory decrease 补偿性减少 referred bythe surgical service 推荐 the pivotal study endorseICI plus chemotherapy asthe most suitable regimen for anycontrol arm in further phase III clinical trials attenuated 减弱的 develop acquired resistance andexhibit natural resistance tertiary 三级的 第三的 underscoringthe need to seek novel therapies with different mechanisms 强调 着重说明 provokes cell cycle arrest 引起了细胞周期阻滞 a promising rationale forfuture clinical application 合理性 The elusive pursuit of progress in limited stage small-cell lungcancer. 难以捉摸的 the dominant mechanismobserved in one biopsy may no longer be relevant in the second biopsy Serial tumorassessments—which this study determined to be generally safe and practicable,with clinically significant complications arising in only 0.7% of patients—aretherefore warranted to guide individual treatment decisions noninvasive methods will be more readilyapplicable the data are still sparse 稀疏的 genomic perturbations notwithstanding 尽管如此
| 
